Lange, Thoralf; Ernst, Thomas; Gruber, Franz; Maier, Jacqueline; Cross, Michael; Müller, Martin C.; Niederwieser, Dietger; Hochhaus, Andreas; Pfirrmann, Markus (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-05)
The BCR-ABL T315I mutation causes resistance to imatinib, nilotinib and dasatinib in chronic myeloid leukemia. Forty BCR-ABL positive patients with imatinib resistance were analyzed for T315I mutated clones after six months on nilotinib or dasatinib treatment by quantitative allele-specific ligation polymerase chain reaction with a sensitivity of 0.05%. Ligation polymerase chain reaction revealed ...